The Dnazyme Anti-insulin-like Growth Factor-IIP3 Inhibited Tumour Growth in a Mouse Model of Human Hepatocarcinoma
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چکیده
منابع مشابه
Anti-insulin-like growth factor-IIP3 DNAzymes inhibit cell proliferation and induce caspase-dependent apoptosis in human hepatocarcinoma cell lines
BACKGROUND Insulin-like growth factor II (IGF-II) is a fetal growth protein and an important proangiogenic factor controlled by four promoters (P), of which P2-P4 are inactive in the adult liver. Reactivation and dysregulation of IGF-IIP3 in particular is associated with the attenuation of apoptosis and increased proliferation in a number of liver cancer cell types. Its involvement in experimen...
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ژورنال
عنوان ژورنال: Current Science
سال: 2019
ISSN: 0011-3891
DOI: 10.18520/cs/v116/i12/2072-2077